Matters needing attention in preparation of n-bromobutane

Matters needing attention in preparing n-bromobutane:

1. During feeding, sulfuric acid reacts with sodium bromide to generate hydrobromic acid, and hydrobromic acid reacts with n-butanol to generate n-bromobutane. Excessive dosage and concentration of sulfuric acid will increase side reactions; If the dosage and concentration of sulfuric acid are too small, it is not conducive to the main reaction, that is, the formation of hydrobromic acid and n-bromobutane.

2, after feeding, be sure to stir evenly.

3. During the reaction, keep the reflux stable to prevent the airway from being absorbed.

4. Pay attention to judge whether the crude product is steamed.

5. When washing the crude product, pay attention to correctly judge the relationship between the upper and lower layers of the product.

6, desiccant dosage is reasonable.