In which medical book did the theory of prescription first appear?

According to Baidu Education, Huangdi Neijing has laid the foundation of TCM prescription science, and comprehensively expounded the treatment principles, pathophysiology, viscera and meridians, health preservation and prevention of TCM, especially the ideas of "monarch, minister, assistant, envoy" and "seven emotions", which played an important role in the formation and development of TCM prescription science.

Huangdi Neijing is divided into Lingshu and Suwen, which is the earliest medical classic in China and one of the four classic works of traditional medicine (the other three are Difficult Classic, Treatise on Febrile Diseases and Shennong Herbal Classic).