What diseases can stem cells treat?

At present, studies have proved that stem cells can treat more than 200 diseases, most of which are chronic diseases.

1, diabetes

Therapeutic mechanism: Using dental pulp stem cells with mesenchymal stem cell phenotype can promote the recovery of islet function, reduce the apoptosis of islet β cells, promote the proliferation and transdifferentiation of islet β cells, enhance islet function and improve insulin resistance in vivo, so as to treat diabetes.

2. Chronic interstitial hepatitis

Therapeutic mechanism: Hepatic fibrosis is that hepatic stellate cells (HSC) are activated and transformed into myofibroblast-like cells, accompanied by the positive proliferation of α -smooth muscle actin (α-SMA), which can produce a large amount of extracellular matrix to promote the formation of fibrosis. The core therapeutic target of anti-hepatic fibrosis is activated hepatic stellate cells. Mesenchymal stem cells are mainly used to treat liver fibrosis and cirrhosis because they directly or indirectly regulate hepatic stellate cells. In terms of related mechanism, in vitro experiments based on cell level found that mesenchymal stem cells can secrete anti-apoptosis and anti-inflammatory cytokines, thus inhibiting the activation of hepatic stellate cells.

3. Stroke

Treatment mechanism: Stem cells can differentiate into neurons after directional guidance, so as to make up for a large number of apoptotic brain cells caused by stroke, improve cerebral blood circulation, promote brain metabolism, repair damaged brain tissue and restore neurological function.

4. Alzheimer's Harmo's disease (Alzheimer's Harmo's disease)

Therapeutic mechanism: The pathological features of Alzheimer's disease are cerebral cortex atrophy, protein deposition and memory neuron decrease, while stem cells have the potential to differentiate into neurons and glial cells. Stem cells replace damaged brain cells with their powerful ability of proliferation and homing. After in vitro proliferation and culture, they are sent back to the patient's brain and migrate and differentiate into neurons. Stem cells can secrete a variety of neurotrophic factors, promote the repair of damaged cells, strengthen the connection between synapses and establish new neural circuits.

5. Arthritis

Therapeutic mechanism: Stem cells have strong self-renewal and proliferation ability and differentiation potential, and have chondrogenic function. They can actively migrate to damaged parts for cartilage repair and reconstruction under the action of microenvironment in vivo, and secrete a variety of bioactive molecules, which have immunomodulatory and anti-inflammatory effects. These characteristics can alleviate and alleviate the clinical symptoms of osteoarthritis, fundamentally improve the cartilage defect of arthritis patients, improve the curative effect, and reduce the pain and side effects of patients in the treatment process. (Xinhua News Agency reports)

These diseases are the tip of the iceberg of stem cell therapy. Studies have shown that stem cells can also treat Parkinson's disease, degenerative sclerosis, leukemia and other blood diseases, psoriasis and other intractable diseases.

As an important biological resource in medical research, stem cells are not only widely used. With the development of medical research, stem cells have been found in bone marrow, fat and teeth, and the activity of dental pulp stem cells in teeth is three times that of other stem cells. With the development of biomedical technology, not only the sources of stem cells are more extensive, but also stem cells can be stored in advance. If you miss the storage of umbilical cord blood stem cells, you can consider the storage of deciduous dental pulp stem cells.

References:

1, Pei. Stem Cell Biology: Science Press, 2003: 4- 15.

2. Xu Yifeng. Observation on the therapeutic effect of human deciduous teeth marrow stem cells combined with hyperbaric oxygen on type 2 diabetic rats [D]. PLA Naval Medical University, 20 19.

3. Guo Shimin, Wei Wei. Research progress of mesenchymal stem cells in the treatment of liver fibrosis and cirrhosis [J]. Liver, 2017,22 (06): 551-553.

4. Interpretation: The latest progress of stem cell therapy for osteoarthritis.