Summarize the impact of the opening of new routes

First, after the opening of the New Route, European merchants and colonizers established direct commercial links between Europe, Asia, Africa, and the Americas, initially forming a vast world market.

Secondly, the center of international trade in Europe shifted from the Mediterranean to the Atlantic coast.

Thirdly, it made an important contribution to the primitive accumulation of capital in Europe.

Fourth, the traditional societies of the Americas, however, were decimated and the Indian population was decimated.

Fifth, it led to the gradual formation of a European-centered world economic system, and the human race began to move from the scattered and isolated development of various ethnic groups to the world as a whole.