Efficacy and Function of Coptidis Rhizoma (2)

Anti-inflammatory, antipyretic and immunomodulatory effects

Coptidis Rhizoma and berberine have similar anti-inflammatory and antipyretic effects as Baotaisong. It can enhance the phagocytosis of white blood cells, activate macrophages and enhance the phagocytosis of reticuloendothelial system without affecting the number of white blood cells. It can inhibit cell division and has synergistic effect with colchicine; It can also inhibit cell respiration and nucleic acid synthesis, and the inhibitory effect on cancer cells is stronger than that on normal cells. Therefore, Coptis chinensis is an immunosuppressant and immunomodulator.

To the digestive system

Coptis chinensis and berberine have two-way regulating effects on gastrointestinal smooth muscle: excitation and inhibition. Low concentration can stimulate smooth muscle, and high concentration can relieve spasm. Berberine has antidiarrheal effect, which can significantly resist diarrhea caused by senna in mice. It may be related to the elimination of intestinal inflammation and edema. Huanglian, berberine and Huanglian Jiedu decoction have obvious protective effects on gastric mucosa and can significantly resist experimental ulcer in rats. Berberine has obvious cholagogic effect, which can promote bile formation and promote the excretion of conjugated bilirubin. Jatrorrhizine is also beneficial to gallbladder function, but its effect is weak and lasting.

Effects on cardiovascular system

Berberine has antihypertensive effect. Its hypotensive mechanism is related to direct vasodilation, inhibition of vascular motor center, anti-adrenaline, inhibition of pressor reflex and anti-cholinesterase. Alkaloids such as Rhizoma Coptidis also have antihypertensive effects. Berberine can excite the heart, increase the coronary flow, significantly improve the hypoxia tolerance of the heart, brain and whole body, and significantly reduce the myocardial oxygen consumption of normal and failed hearts. Jatrorrhizine and berbamine can reduce the range and degree of experimental myocardial infarction. Berberine and jatrorrhizine can antagonize arrhythmia caused by adrenaline. It can significantly reduce ventricular premature beats and ventricular tachycardia induced by mice. Jatrorrhizine also has significant antiarrhythmic effect. ?

Regulate blood, blood lipid and blood sugar

Berberine has obvious inhibitory effect on platelet aggregation. Berberine has significant lipid-lowering effect and can significantly reduce the increase of serum cholesterol in mice. Berberine has hypoglycemic effect on experimental hyperglycemia F mice. Its mechanism is related to the inhibition of liver glycogen heterogenesis and the promotion of grape glycolysis, but has nothing to do with insulin secretion.

Impact on internal processes

Berberine is less absorbed in the gastrointestinal tract, and quickly distributes in all tissues of the whole body after entering the blood, and the blood concentration is low. Berberine can be rapidly metabolized into carbonate substances in the body and excreted after defecation.

Other functions

Central inhibition: Berberine and coptis alkaloids have central inhibition, but they have sedative and analgesic effects. Coptis alkaloids have many functions, such as increasing saliva secretion, reducing intraocular pressure, antidiuretic and stimulating ACTH secretion.

Application of coptis chinensis

Damp-heat fullness, vomiting and acid swallowing. Especially good at clearing the heat of middle energizer, it is often used with Suye Huanglian Decoction to treat abdominal distension, nausea and vomiting caused by damp-heat blocking middle energizer and poor qi movement. Or Scutellariae Radix, Rhizoma Zingiberis Recens, and Rhizoma Pinelliae, such as Banxia Xiexin Decoction. Combined with gypsum, it can treat vomiting caused by stomach heat, such as Shi Lian powder.

Damp-heat diarrhea This product is an important medicine for diarrhea, and it is effective when used alone.

High fever leads to lethargy and insomnia, and vomiting due to blood heat is particularly beneficial to clearing the excess fire in the heart meridian, which can be used to treat lethargy and irritability syndrome caused by excessive heart fire.

Carbuncle, swelling, furuncle, conjunctival congestion, toothache

Xiaoke Qingwei Fire can be used to treat the syndrome of excessive stomach fire. It is often used with Ophiopogon japonicus, such as Xiaoke Pill.

Externally used to treat eczema, wet sores and pus in ear canal. Can be made into topical ointment for treating eczema and eczema. The soaked juice can be used in the affected area to treat pus in the ear canal. Dropping the decoction on the eyes can cure pinkeye.

Application of Huanglian Miaofang

Huanglian decoction

Coptidis Rhizoma 10g, put into a medicine pot, decoct in water for 30 minutes, and take juice, two or three times a day. Indications: fever, dysentery and vomiting.

Huanglian Ejiao decoction

Coptidis Rhizoma 12g, Scutellariae Radix 6g, Radix Paeoniae Alba 6g, Colla Corii Asini 9g, and Wuji 10g. First, put the first three herbs into a casserole, add water and decoct for 30 minutes to get juice, then add donkey-hide gelatin and black-bone chicken, and mix well. Daily 1 dose, taken twice. Indications: hyperactivity of fire due to yin deficiency, insomnia and upset.

Huanglian Jiedu decoction

Put 9 grams of Coptidis Rhizoma, 6 grams of Scutellariae Radix, 6 grams of Cortex Phellodendri and 9 grams of Gardenia together in a casserole, add water and decoct for 30 minutes, and take the juice. Daily 1 dose, taken twice. This prescription has the efficacy of clearing away fire and detoxifying, and is mainly used to treat various diseases caused by excessive heat and toxin.

Huanglian porridge

Coptidis Rhizoma 10g, sugar 15g, and japonica rice 50g, boiled in water to make porridge. Eat it every morning and evening

Fried winter melon with coptis chinensis

Coptidis Rhizoma 10g, wax gourd 250g, salt and monosodium glutamate 2g, soy sauce and cooking wine 5ml, chopped green onion 6g and Jiang Mo 6g, stir-fry. Eat with meals.

Steamed pork tripe with coptis root

Coptidis Rhizoma10g, pork tripe 250g, salt and monosodium glutamate 2g each, chopped green onion 6g and Jiang Mo 6g each, soy sauce and cooking wine 5ml each, steamed until the pork tripe is cooked. Eat with meals.

Huanglian sanzicha

5 grams of Coptidis Rhizoma, 5 grams of Ligustrum lucidum 10, 0 grams of Lycium barbarum 10, 0 grams of Semen Astragali Complanati 10, put them in a thermos cup, brew them with appropriate amount of boiling water, and cover them for about 15 minutes before drinking.

Matters needing attention in the use of Rhizoma Coptidis

(A) the use of Coptis should pay attention to adverse reactions.

Overdose

Excessive use of Rhizoma Coptidis can cause nausea, vomiting, shortness of breath and spasm. Conventional doses are safer. There are patients with acute cardiogenic cerebral hypoxia syndrome induced by intravenous drip of berberine due to diarrhea. Berberine injection should be avoided as much as possible.

anaphylactic reaction

Oral coptis powder or berberine, injection of berberine has allergic reaction. Most of them occur within a few minutes after taking the medicine, showing dizziness, nausea, vomiting, chest tightness, shortness of breath, systemic rash, fever, and even laryngeal edema, confusion, blood pressure drop and anaphylactic shock.

Misdiagnosis syndrome

Coptis chinensis is a bitter and cold product with strong catharsis, which is easy to hurt Yang Qi.

(2) Coptis taboo.

Coptis chinensis is suitable for people to eat.

Use with caution in patients with epigastric pain, diarrhea due to spleen deficiency and diarrhea due to five-variable kidney disease.

Coptis chinensis food phase grams.

Coptidis Rhizoma, Flos Chrysanthemi, Flos Genkwa, Radix Scrophulariae, Semen Dictamni and Bombyx Batryticatus; Afraid of coltsfoot; Avoid pork.

berberine

(1) What is berberine?

Berberine is an alkaloid, which has been used in China for a long time. It can be extracted from plants such as Coptidis Rhizoma, Cortex Phellodendri, and Sanzhen. Has obvious bacteriostatic effect.

Berberine is one of the most widely known drugs for treating diarrhea, which is cheap, simple to take and easy to carry. Therefore, almost every household has this medicine. Berberine is one of the essential medicines for people, whether on business trip or traveling. Many people think of diarrhea for the first time.

Berberine is a good medicine, but it should not be used indiscriminately, so choose the right one. First of all, Berberine is not suitable for systemic infectious diseases, because it is poorly absorbed orally and almost stays in the gastrointestinal tract, so it is not easy to enter the blood through the gastrointestinal tract, so it is only suitable for inflammatory diseases in the gastrointestinal tract.

(B) the role of berberine

Effects on hyperlipidemia and diabetes.

The latest clinical research shows that berberine has a good preventive and therapeutic effect on hypertension, hyperlipidemia, diabetes, arrhythmia, cancer and other diseases.

After a course of treatment with berberine for hyperlipidemia (0.3g each time, three times a day for 20 days), the total cholesterol and triglyceride in blood decreased obviously, which is effective for coronary heart disease and cerebrovascular disease caused by arteriosclerosis.

Berberine also has the effects of lowering blood sugar and urine sugar. Diabetic patients can take 0.4 g orally, four times a day. After taking 1-3 months, blood sugar can drop to normal level.

Effects on the heart

Arrhythmias in middle-aged and elderly people are mostly related to organic heart diseases, such as coronary atherosclerotic heart disease and myocarditis. Oral berberine, 0.4g each time, 4 times a day for 7- 12 days, can relieve or eliminate discomfort symptoms such as palpitation, shortness of breath and chest tightness, and can relieve or correct arrhythmia. Scientific research results show that berberine can increase coronary blood flow and improve myocardial function, thus reducing the incidence of arrhythmia caused by coronary artery infarction.

Effect on cerebral ischemia

Berberine also has a good effect on preventing and treating transient ischemic attack. Transient ischemic attack is an important risk factor for cerebral embolism. If not controlled in time, about half of them can induce cerebral embolism, leading to life-threatening. Because the occurrence and prognosis of transient ischemic attack are closely related to platelet aggregation, aspirin and other antiplatelet aggregation drugs have long been effective drugs for treating transient ischemic attack and preventing cerebral infarction.

Berberine, like aspirin, can inhibit platelet aggregation and has a wider range of effects, so it is a more effective drug than aspirin. Berberine can be used in the treatment of transient ischemic attack, which is easily accepted by patients because of its wide drug sources and small side effects. Specific usage: 0.9 g per day, taken orally three times, with 30 days of continuous treatment as a course of treatment, which can be used for 2-3 courses.

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