Therapeutic principle of traditional Chinese medicine iontophoresis instrument

1. Pretreatment of skin with high temperature and application of accelerant (hydrating agent and exfoliating agent) to increase skin permeability; Polypeptides with a- helix structure are reversed by pulse current to form parallel arrangement, which changes from disorder to order, resulting in biological channels that allow biological macromolecules to pass through. It is believed that drugs can pass directly, so that drugs can pass smoothly. Through electrophoresis and iontophoresis, drug particles are fully activated by water, which is beneficial to transdermal transport of particles. The synergistic effect of the above methods promotes the effective transport of drugs into the body. Combined with the meridian theory of traditional Chinese medicine, it can be dredged by stimulating the corresponding acupoints.

2. Factors affecting drugs:

A, skin pretreatment, including the application of hyperthermia and accelerant, increased the permeability of local skin.

B, the higher the drug concentration on the substrate, the faster the drug enters the body.

C, a certain range and density of formation strength directly affects the speed and range of drug penetration.

D, the current intensity of iontophoresis is directly proportional to drug penetration in a certain range.

E, seepage velocity, the site of transdermal drug delivery, feet, forearms, instep, scalp, groin and behind ears were added in the following order.

In addition, skin PH and other conditions will also affect transdermal drug delivery.