Preparation of n-bromobutane how to reduce the generation of side reactions

When adding materials, add concentrated sulfuric acid in water and wait until cooled to room temperature, then add n-butanol and sodium bromide; sodium bromide should be finely ground, and should be added in batches. Shake frequently during the reaction to prevent sodium bromide from caking and make full contact with the reactants; strictly control the reaction temperature, keep the reaction liquid in a slightly boiling state; add the right amount of water to dilute the concentrated sulfuric acid when adding materials.

1-Bromo n-butane has aliphatic bromide properties, active chemical properties, can react with a variety of compounds. Hydrolyzed in a hot aqueous solution of a strong base to produce alcohols and salts. It reacts with ammonia to form butylamine bromide and with sodium cyanide to form n-pentanenitrile and sodium cyanide.

Extended information:

Bromine and sulphur are first added to a reactor fitted with stirring. After that, the alcohol-water mixture is added dropwise, refluxed after addition, the crude bromobutane is evaporated, washed with dilute alkaline water and dried to obtain the product.

N-butanol in the presence of sulfuric acid and hydrobromic acid reaction, n-butanol and sulfuric acid mixture, dropwise addition of sulfuric acid, heating reflux, distillation, drying to get bromine n-butane.

Mixing n-butanol with hydrobromic acid, adding sulfuric acid dropwise, heating and refluxing the reaction for 1.5h, distilling to get the crude product of bromobutane, washing it with water to pH 6~7, and dehydrating it with anhydrous calcium chloride to get it.

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