Traditional Culture Encyclopedia - Traditional stories - Three Summaries of Practice in Pharmaceutical Factory
Three Summaries of Practice in Pharmaceutical Factory
Summary report of pharmaceutical factory practice
I. Overview of Mintai Pharmaceutical Factory. Xx Pharmaceutical Factory Co., Ltd., formerly the Eighth xx Pharmaceutical Factory, was founded in 1987. The factory is located at the foot of Changbai Mountain with beautiful scenery and surrounded by mountains, xx Industrial Park. The company covers an area of 50,000 square meters with a building area of 20,000 square meters. It has four production lines for pretreatment and extraction of traditional Chinese medicine, tablets, capsules and granules, as well as a quality inspection center with complete facilities and advanced instruments. The company has 560 employees, including professional and technical personnel 128, and all kinds of professional and technical titles above the intermediate level account for 30% of the total employees. Mintai Pharmaceutical Factory has become a modern pharmaceutical enterprise integrating scientific research, development, production and sales. Business philosophy: concentrate all resources, conduct in-depth research, professional innovation and professional services in related fields.
Second, the internship task.
At first I was in the production workshop, and later I was transferred to the laboratory. Mainly learned how to identify drugs, check whether drugs are qualified, and check microbial limits.
Third, the internship content.
Prepare a silica gel plate, grind and mix 1 part stationary phase and 3 parts water in a mortar, pour into a coater, move the coater smoothly on a glass plate for coating, dry in the sun, and activate at 105% for 30 minutes. Loss on drying weighed 65438±0g of the drug to be tested, put it in weighing bottle, and dried it to constant weight at 65438 005 degrees Celsius, and the weight loss should not exceed 65438 00%. Disintegration time, electronic balance, etc. Microbial limit test.
(1) Sterilize all utensils, wrap straws and plates with kraft paper, sterilize at 165℃ for 4 hours, and take them out for later use.
(2) Before the experiment, the console was disinfected, ventilated and sterilized by ultraviolet rays with Sur disinfectant. After washing your hands with hand sanitizer, put the required items into the bacteriological examination room through the transfer window for experiments. Wear clean clothes, masks and gloves when operating, and prepare at least two boards for each sample.
(3) Prepare a buffer solution of sodium chloride-peptone with PH7 for the sample, and take dipotassium hydrogen phosphate, disodium hydrogen phosphate, sodium chloride and peptone, with 90 ml of liquid sample and 100 ml of solid sample. Culture medium, nutrient agar medium and tiger red agar medium, each dish is about 15 ml. After the configuration is completed, put it into a sterilizer and sterilize it for 12 1 celsius, 15 minutes. Put it in the refrigerator and keep it frozen.
(4) Medicinal materials containing animal tissues should be examined for Salmonella. Pour 10g powder into 200ml nutrient broth culture medium, shake it evenly, put it in a bacterial incubator for18 ~ 24h, take it out, suck out 1ml, put it in bright green, cultivate it, take it out the next day, and inoculate it in bile salt sulfur milk and Mai Kangkai with an inoculation ring.
(5) Learn how to determine and use the suspended particle dust detector and the determination of purified water.
Fourth, the internship sentiment.
During my internship, I made full use of what I learned in school and improved my skills. Compared with the old employees who have been employed for many years, the newly graduated students are far behind in both skills and experience. I think the knowledge in books is of course important, but the school should let students have more contact with practice, so that they can leave a good impression on the company during their internship and let our Changbai Mountain Vocational and Technical College develop better. However, this internship also has many shortcomings. For example, students' living environment, lifestyle and ideas in school are very different from those in society. These eight-month internship can't completely transform us into real staff. Therefore, no matter where you work in the future, you should integrate your body and mind into this society and become a member of it.
Fifth, internship suggestions.
Summary report of internship in the second pharmaceutical factory
In the early days, I used this time to conduct a three-day observation internship in xx Pharmaceutical, and learned a lot of knowledge. Practical purpose:
By visiting and experiencing the production process of the chemical plant workshop, you can get in touch with your academic knowledge, understand the situation and prepare for future employment.
Practical content:
Visit the ethylene oxide production workshop and ask engineers, technicians and workers. And connect what you have learned in school with real life production.
I introduction of xx pharmaceutical co., ltd
Xx Pharmaceutical Co., Ltd. is a large-scale pharmaceutical and chemical comprehensive enterprise integrating science, industry and trade, mainly engaged in the production of pharmaceutical raw materials and intermediates, food additives, daily chemical products and medical devices, the development and transfer of new pharmaceutical products and technologies, and the production and sales of fine chemical products, namely, the production of ethylene oxide, a series of pharmaceutical intermediates mainly based on sodium taurocholate, a series of medical devices mainly based on traditional Chinese medicine decocting machines, and a series mainly based on sodium hydroxyethyl coconut oil sulfonate. Among them, the annual output of taurine is 65,438+0,000 tons, the quality standards are jp8 and vsp26, and 80% of the products are exported to Europe, America, South Korea and Southeast Asia.
In recent years, xx pharmaceutical industry has developed rapidly, becoming a key backbone enterprise in xx county, and being rated as a big taxpayer in xx county every year.
Second, the theme of the report
1, chemical principle
Ethylene oxide is a colorless gas at room temperature and a colorless liquid at low temperature. It smells of ether and is poisonous. It is a colorless gas at room temperature and a colorless liquid at low temperature. It smells of ether and is poisonous. There are usually two methods: the first is ethylene oxidation, and the second is dechlorination of chloroethanol. The factory adopted the first method, that is, oxidation method, in which ethylene reacts with peroxide, and peroxide makes the double bond of ethylene undergo affinity addition, thus generating ethylene oxide. Because ethylene, peroxide and ethylene oxide are flammable and explosive, there is no actual equipment in the workshop for safety reasons.
2. Production of raw materials
As xx is adjacent to Wuhan, the ethylene project in Wuhan is a petrochemical project in the central region at present, and there are many manufacturers producing peroxide in Wuhan, with rich sources of raw materials.
3. Production process
Powdered peroxide is put into all parts of the reaction kettle, and a large amount of ethylene gas is introduced into the reaction kettle, and the reaction temperature is controlled at low temperature, generally at-10 ~ 20℃. First, ethylene oxide can be liquefied and easy to collect; Secondly, the liquid phase produced according to Le Chatelet principle is beneficial to yield; Thirdly, many side reactions at high temperature are avoided; Fourth, avoid high-temperature explosion.
4. The loading of ethylene oxide
Ethylene oxide is a flammable, explosive and easily polymerized substance. In air 1 atmospheric pressure, the explosion limit is 3%- 100% by volume. Therefore, the storage and transportation requirements of ethylene oxide are very strict, and it is generally sealed with nitrogen. Use special ethylene oxide tanker to transport.
Third, summary.
During this holiday, my internship in the workshop increased my knowledge and experience, and also increased my practical knowledge, which was very rewarding and moving. In these days' activities, I have at least strengthened one point-to develop the economy, we must have a long-term vision, knowledge and technology. This internship, I also strengthened a belief-to study hard knowledge and skills and make contributions to the future development of China's economy.
Summary report of internship in the third pharmaceutical factory
I. Purpose of internship 1. Through visiting and studying in the workshop of pharmaceutical factory, I learned about the basic equipment and layout of some workshops.
2. Listen to the introduction of relevant management and technical personnel, so that everyone can have a basic impression on pharmaceutical enterprises.
3. Have an intuitive understanding of the work of pharmaceutical factories and the production technology of related drugs, and understand the machinery and equipment used in pharmaceutical technology and related processes;
4. It is helpful to combine theory with practice in school, understand the specific application of professional knowledge in real social work, and deepen the understanding of theoretical knowledge.
5. This internship in the pharmaceutical factory has a comprehensive understanding of the possible working environment in advance, which is conducive to finding a suitable position in the future employment position, clarifying the route of future employment, and having a certain understanding of how to apply professional knowledge to actual production and life after entering the society.
Second, the internship unit profile
Xx Pharmaceutical Factory is a school-run industry that combines the production and operation functions with the practical teaching functions of Hubei Medical College, a national key technical secondary school. It is the teaching practice base of Tongji Pharmaceutical College of Huazhong University of Science and Technology and Hubei University of Technology. Its tablets, capsules and granules all passed the GMP certification organized by the state, and obtained the GMP certificate issued by the former State Administration of Pharmaceutical Products in February 2002. At present, it can produce tablets, hard capsules and granules 12 preparation products. The annual output is 200 million tablets, 50 million capsules and 0/50,000 bags of granules, which can accommodate 50 students for production training at one time.
Third, the internship content
1, visit the production workshop of pharmaceutical factory.
(1) Understand the layout of pharmaceutical factories and workshops.
On X, X, we arrived at xx Pharmaceutical Factory by bus, and under the leadership of the pharmaceutical factory, we started this internship in the pharmaceutical factory. First of all, the leaders of the pharmaceutical factory introduced the factory layout and workshop layout of Yikang Pharmaceutical Factory to us, and the workshops were arranged according to a certain process to achieve the purpose of convenience and efficiency. In order to facilitate students' practice, xx Pharmaceutical Factory has distributed several important workshops near the corridor to facilitate students' observation and study.
(2) familiar with the pharmaceutical production process
Under the leadership of the relevant leaders of the pharmaceutical factory, each of our classmates put on shoe covers and officially entered the pharmaceutical production workspace of xx Pharmaceutical Factory. Xx Pharmaceutical Factory strictly implements the principle of separating people flow from logistics to ensure the sterility of drugs. In some special pharmaceutical workshops, workers also need to wear special sterile work clothes. Throughout the pharmaceutical workshop, all staff must wear white coats and work caps. When the goods are transported to the pharmaceutical workshop on the second floor by elevator, they must undergo strict sterilization and disinfection to ensure every working procedure.
2. Visit the quality inspection department of the pharmaceutical factory
The quality inspection department of the pharmaceutical factory is on the second floor of another building. The quality inspection department is divided into drug sample storage room, drug inspection room and microbial inspection room. The quality inspection department also has many instruments for detecting drugs, such as HPLC, dissolution accelerator, pulverizer, tablet press and so on.
Fourth, the internship results and feelings
Although this internship is over, this experience has had a great impact on my education. Practice is a practical means for us to improve our understanding. Because of the short internship time, I can only have a general understanding of the general structure and basic process of the pharmaceutical production and packaging workshop, and what the real pharmaceutical production is about, but it also makes the knowledge learned in books concrete and visual, and personally experiences the strict requirements of the pharmaceutical workshop on hygiene and the strict working attitude of the staff, so that students can have a new understanding and understanding of themselves and their majors. It not only gave me a new understanding of pharmaceutical technology in theory, but also made me feel the importance of combining theory with practice, which increased my knowledge and broadened my horizons.
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