Treatment of Damp-Heat Diarrhea

I. Bai Tu Weng; Huang Lian; Huang Bai

According to modern medical research Bai Tu Weng, Huang Lian and Huang Bai have a wide range of antibacterial effects. It has inhibitory effect on dysentery bacillus, Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, typhoid fever, paratyphoid fever, cholera, and amoebic trophozoites. The white head of the intestinal mucosa has an astringent effect, so it can stop diarrhea and bleeding, and with other in.

II. Huo Xiang Zheng Qi San (water. Pills)

Origin of the prescription Song - "Taiping Huimin Hejiaobu Fang". Chinese Pharmacopoeia (1990 edition).

Dosage Forms Pills; Capsules; Soft Capsules; Punch

Drug Composition Patchouli, Dahua Pi, Angelica dahurica, Perilla frutescens, Poria, Semixia, Atractylodes macrocephala, Atractylodes macrocephala, Pericarpium chenopodium, Huperzia, Platycodon grandiflorus, Glycyrrhiza glabra.

Additions and subtractions

Effect Resolving exterior dampness, regulating Qi and harmonizing the middle.

Attending External wind-cold and internal dampness. Vomiting and diarrhea in cholera, fever and malignant cold, headache, chest and diaphragm fullness, pain in the abdomen and stomach, white and greasy tongue, and miasma malaria. It is used in the treatment of colds, acute gastroenteritis, acute and chronic colitis, urticaria, acidosis, ringworm dermatitis and so on.

Preparation method

Use and dosage Pills: water pills, 6g each time for adults, 2-3 times a day orally. Aqueous: 10ml each, adults 5-10ml each time, 2 times a day orally, acute patients should be served more frequently, children discretionary reduction. Capsule: 3-4 capsules per time for adults, 2-3 times a day orally. Soft capsule: 2-4 capsules each time, 2 times a day orally. Punch: 5g per time, 2 times daily oral.

Contraindications for use Do not take if there is a deficiency of yin and fire. Avoid cold and greasy food.

Adverse reactions The toxicity of this formula is very low, but Huo Xiang Zheng Qi Shui is a liquid preparation containing 40%-50% ethanol, so it can often cause alcohol-like reactions in children, women, the elderly and patients who do not drink alcohol. Very few patients oral patchouli Zhengqi water caused allergic rashes, after stopping the drug or with anti-allergic treatment, the symptoms soon disappeared.

Clinical application l. Infantile diarrhea: add and subtract with this formula: Huo Xiang 5-10g, Dabai Pi 5-10g, Zisu 4-6g, Atractylodes macrocephala 5-15g, Angelica dahuricae 5-10g, Poria cocos 5-5g, Houpu 5-10g, Semen xia 4-6g, Pericarpium chenpi 5-10g, Platycodon grandiflorus 5-10g, Glycyrrhiza glabra 3-5g. 1 dose per day, decocted in water to 80-100ml, and taken orally in 3-5 times. Take it orally 3-5 times. For those who have watery stools, add poria 5-10g, for those who have no fever, go to Angelica dahurica, Platycodonopsis, Sophora, and for those who have no vomiting, go to Semixia, Angelica dahurica, Sophora, Platycodonopsis. Those with high fever and frequent vomiting are given appropriate amount of intramuscular injection of analgin, Aimaoer, and those with obvious dehydration are given one-time intravenous rehydration. Treatment of diarrhea in infants and young children 96 cases, of which 46 cases of male, female 50 cases; less than 6 months 3 cases, 6 months to 3 years old 93 cases; with fever 21 cases, with vomiting 34 cases. Results: Fever and vomiting stopped, fecal pattern returned to normal, and infants less than 6 months old had less than 4 bowel movements per day, and infants 6 months to 3 years old had less than 2 bowel movements per day, which was regarded as cured. Among them, 8 cases of diarrhea stopped in 12-48 hours after the medicine, 24 cases of diarrhea stopped in 48-72 hours, 85 cases were cured, 6 cases were effective, 5 cases were ineffective, the cure rate was 88.5%, and the total effective rate was 94.7%, with an average of 7 days to cure.

There are also reports that this formula is made into tablets, 1-8 tablets each time, with a gauze bag decocted into 20 ml, served 3 times a day. Treatment of infants and young children in autumn diarrhea 64 cases, the age of the youngest 6 months, the oldest 2 years old; the shortest duration of half a day, the longest 6 days. Results: the number of days to stop diarrhea was significantly different from that of the control group. It shows that the treatment of diarrhea with this decoction has a quick effect.

2. Acute alcoholism: add and subtract with this formula: patchouli, Su leaf, half-summer 12g each, atractylodes macrocephala, Poria, the belly skin 15g each, Park 10g, licorice, Angelica dahurica 6g each, Platycodon grandiflorus 10g, ginger 3 slices, 5 jujubes, sand nuts, wood incense 10g each, Pueraria lobata 30g. 1-2 doses of daily decoction. Treatment of acute alcoholism 61 cases. Results: 56 cases of effective, ineffective 5 cases, the number of effective doses 1-4 doses, the average of 2 doses.

3. Acute gastroenteritis: this formula is made of punch for the treatment of acute gastroenteritis group of 150 cases, male 67 cases, female 83 cases; of which 104 cases of adults, children 46 cases. There are also 40 cases of water control of this formula. All cases are recognized by Chinese medicine practitioners as externally affected by wind-cold and internally injured by dampness. Treatment: Adults 1 bag (5g) each time, 2 times a day, children reduce. 3 days for a course of treatment. Results: clinical recovery (vomiting, diarrhea, abdominal pain symptoms disappeared, stool test normal) 95 cases, accounting for 63.3%; improvement (vomiting, diarrhea significantly reduce the number of times, nausea, abdominal pain and other symptoms to reduce) 55 cases, accounting for 36.7%; invalid 0; the total effective rate of 100%. The total effective rate of the aqueous control group was 97.5%.

4. Acute food poisoning: add and subtract with this formula: Huo Xiang 15g, Su Ye, Angelica dahurica, Chen Pi, half-summer 9g each, Atractylodes macrocephala, Poria, thick Park, abdominal skin 12g, Platycodon grandiflorus, licorice 6g each, 3 slices of ginger, 4 jujube. Day 1 dose of decoction, divided into 3 times a day or drink frequently. Vomiting is very add Huanglian 3g; diarrhea frequent number of dehydration, add ziziphi shell 6g, and the use of oral rehydration auxiliary treatment. Treatment of acute food poisoning 33 cases, 29 cases in the control group to Western medicine (gentamicin 240,000 units added to the liquid drip-based, part of the cases combined with oxytetracycline, dysentery and other drugs routinely taken orally, and according to the need for the application of anodyne, chaihu injection, epilepsy, love Mauer and so on) treatment. RESULTS: The two groups were all cured, the treatment cure time was 52 hours in the traditional Chinese medicine group and 56 hours in the control group, there was no significant difference between the two groups, but the traditional Chinese medicine group was significantly better than the control group in relieving fever, head and body ache, abdominal distension, abdominal pain, and other symptoms and post-disease recovery, the average time for fever reduction was 37 hours, and 52 hours in the control group (P<0.01), which is a significant difference.

5. Prickly heat: this formula is made into water, wash with warm water, try on the affected area, and apply patchouli water locally. 3-4 times a day. Treat 30 cases of prickly heat. Results: 27 cases were cured, 3 cases were transferred to other medicines due to local secondary infection into prickly heat.

Pharmacological effects Mainly antispasmodic, analgesic, antiemetic, enhance cellular immune function, antibacterial and other effects.

1. Antispasmodic: Huo Xiang Zheng Qi Wan (water) on the rabbit isolated duodenum has obvious inhibitory effect, and can fight against cholagogues caused by intestinal spasm; cholagogues caused by dogs and rabbits in vivo intestinal spasm has obvious inhibitory effect. It can counteract the intestinal spasm induced by salicylic acid lentinanine, and its effect is similar to that of atropine on intestinal spasm. The spontaneous activity of isolated intestinal smooth muscle has an inhibitory effect, and can counteract the intestinal spasm caused by barium chloride, so there is still a direct inhibitory effect on intestinal smooth muscle. Huo Xiang Zheng Qi Shui has good antispasmodic effect on the automatic contraction of isolated guinea pig and rabbit duodenum and on the ileal contraction caused by histamine, acetylcholine and barium chloride; and it can antagonize the uterine contraction induced by posterior pituitary hormone in mice. Huo Xiang Zheng Qi capsule also has obvious antispasmodic effect, the concentration of 8.55xl0-4g/ml, the isolated rabbit intestinal normal inhibition rate of 73.8%, and can inhibit acetylcholine, barium chloride-induced intestinal spasm in rabbits, and the inhibition rate of 61.0%, 68.3%, respectively. The low concentration of Huo Xiang Zheng Qi Wan had a bidirectional regulating effect on the motility of isolated rabbit small intestines, while the high concentration showed a complete inhibition and antagonized acetylcholine.

2. Analgesic: Huo Xiang Zheng Qi water has obvious analgesic effect on acetic acid stimulated pain reaction (twisting method). Huo Xiang Zheng Qi capsule has antagonistic effect on the analgesia of antimony potassium tartrate; on the pain caused by the hot plate method, the pain threshold is increased by 10% in 90 minutes.

3. Gastrointestinal peristalsis propulsive effect: patchouli Zhengqi water and capsule solution on the mouse gastrointestinal tract conveyor function has a significant effect on the administration of the group propulsive rate is slower than that of the control group, suggesting that there is an inhibitory effect on the in vivo gastrointestinal tract smooth muscle peristalsis.

4. Antiemetic: 11.4% patchouli capsule solution 20ml/kg to domestic pigeons, 5 minutes after each domestic pigeon into the 1.5% copper sulfate solution 20ml/kg, its vomiting latency and vomiting number of comparisons with the control group, there is a significant difference between, indicating that the drug not only does not vomit, but also has the effect of antiemetic.

5. Enhancement of cellular immune function: with magnesium sulfate to diarrhea styled mice, treated with patchouli Zhengqi Pill, its peripheral blood lymphocyte infiltration 3H-TdR index increased, while the control group is lower than the normal group (does not lead to diarrhea), and the administration of the group is close to the level of the normal group. It was revealed that Huo Xiang Zheng Qi Wan could improve the immune function of mice and promote the repair of damaged intestinal segments.

6. Increase the absorption function of gastrointestinal tract: After the mice with diarrhea styling were treated with Huo Xiang Zheng Qi Pill, the absorption of glucose and water in their blood and liver tissues was increased, so that the animals could restore the absorption function of gastrointestinal tract for sugar after stopping diarrhea.

7. Antibacterial: Huo Xiang Zheng Qi Shui has antibacterial effect on Garcinia cambogia and other 8 kinds of bacteria, especially on Garcinia cambogia and Staphylococcus aureus. And it has strong inhibitory effect on A, B paratyphoid bacillus, red trichophyton, gypsum-like trichophyton, flocculent epidermis, cerebral trichophyton, gypsum-like microsporidium, Candida albicans, Cryptococcus neoformans, and dermatitis bacterium.

Toxicity test Acute toxicity: healthy mice were dosed with 53.2% patchouli capsule solution 25 ml/kg (equivalent to 583 times the human dosage) twice a day, observed for 7 days, the animals' activities were normal, and none of them died.

The article is reproduced from the medical full online

Three. Job's tears and red bean soup

is the best prescription for removing dampness from the body. (Wu Guozhong: Job's Tears and Red Soy Bean Porridge - Dispel Dampness and Keep All Diseases at Bay)