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Gynecological examination and routine examination of the white belt, to see if there is no inflammation, but also can check mycoplasma, chlamydia and TCT. ultrasound, to see if there is no abnormality of the uterus and adnexa. Check the blood eugenics four, immune antibodies, thyroid function triple test and other tests needed in early pregnancy. If menstruation is not normal, check the endocrine six on the second to fifth day of menstruation. To supplement folic acid to prevent neural tube malformation.