My father needs a hematopoietic stem cell transplant. I'm a semi-donor. I want to ask, what is the process of donating hematopoietic stem cells to him, and what kind of promoting cells should be used?

Volunteers collect hematopoietic stem cells.

At present, there are two main ways to collect hematopoietic stem cells. One is to extract bone marrow hematopoietic stem cells: the volunteers are given general anesthesia or local anesthesia, and bone marrow blood is extracted from the volunteers' ilium; The other is collecting peripheral blood stem cells: injecting mobilization agent into volunteers, collecting blood components and collecting peripheral blood hematopoietic stem cells of volunteers. At present, the latter is widely used, while the former is basically not used.

① Volunteers injected mobilization agent to mobilize hematopoietic stem cells from bone marrow into peripheral blood. The medical staff will inject the mobilization agent into the volunteers 3-5 days before the first collection, usually once a day/kloc-0, and the collection will start 3-5 days after the injection.

② Collection of bone marrow hematopoietic stem cells: First, the whole blood was collected from volunteers' arm veins, and hematopoietic stem cells were extracted by a blood cell separator, while other blood components were returned to volunteers.

The patient underwent a transplant.

① Bone marrow cleaning of patients: Before hematopoietic stem cell infusion, patients will receive high-dose chemotherapy or chemotherapy combined with whole body radiotherapy, so as to kill the residual malignant cells in the body as much as possible and prepare "space" for hematopoietic stem cells of volunteers, that is, suppress the immune systems of both volunteers and patients and avoid mutual rejection.

② Transplantation: the hematopoietic stem cells of volunteers were imported. The infusion of hematopoietic stem cells is similar to blood transfusion, unlike general surgery. Hematopoietic stem cell suspension bag is sent to the aseptic warehouse where the patient is located, and the nurse immediately hangs it on the patient infusion rack to give the patient infusion.

After reading the basic process of donating hematopoietic stem cells and hematopoietic stem cell transplantation, do you have a certain understanding of donating hematopoietic stem cells?