What medicine should depression take?

Tricyclic antidepressants: they are commonly used antidepressants at present.

1, mainly imipramine, amitriptyline, doxepin, clomipramine, norimipramine, etc. Its pharmacological action is related to blocking the reuptake of norepinephrine and serotonin in the brain, which can inhibit the reuptake of norepinephrine and serotonin by the presynaptic membrane of nerve endings, thus increasing the transmitter concentration in the receptor site and playing an antidepressant role.

2. Bicyclic and tetracyclic antidepressants: Maprotiline, as the representative, has similar pharmacological effects to tricyclic antidepressants.

3. Monoamine oxidase inhibitors: reversible and irreversible, with moclobemide as the representative of reversibility and phenelzine as the representative of irreversibility. Because of their high toxicity, these drugs are rarely used now. Its pharmacological function is to inhibit monoamine oxidase, reduce the degradation of norepinephrine, 5- hydroxytryptamine and dopamine, increase the content of catecholamine in the brain, and play an antidepressant role.