Great innovation in liver cancer screening technology, finding cancer fingerprint ctDNA with a drop of blood.

Air pollution is super serious! This artifact reduces the pain caused by wearing a mask for a long time. China Research: Cancer genes accelerate the growth of antlers and help to find new ways to fight cancer. Proton application technology, anti-cancer, anti-radiation detection are all proficient in Taiwan Province Province initiative! The "spinal tractor" adopts a backward design, which effectively reduces the risk of surgery. Without hepatitis B and C, fatty liver also increased the proportion of people suffering from liver cancer in Taiwan Province Province. At present, domestic researchers have proposed an early screening and prevention mechanism for liver cancer screening. A small amount of blood is used to detect the methylation degree of circulating tumor DNA(ctDNA) at specific sites, and combined with the unique patented technology of liver cancer methylation prediction model, it is expected to improve the screening performance of liver cancer, so that the silent killer "liver cancer" can be found early and treated, and the treatment effect of patients can be greatly improved.

CtDNA is the fingerprint of cancer.

When cells rupture or die, they will release all kinds of DNA in the cells and let them free in the circulating blood. Under normal circumstances, these free substances will be removed by macrophages, but when the proliferation rate of tumor cells is faster than the removal rate, ctDNA will have the opportunity to continue to be free in circulating blood. Lv Changyi, a researcher of Hualian Biotechnology Methylation Project, said that it has been confirmed that ctDNA is the free DNA of tumor in patients' blood, and it is a tumor marker with high sensitivity and specificity, which is equivalent to the "identity fingerprint" released by tumor cells in blood. Because the methylation changes it carries are quite consistent with the primary tumor tissue, ctDNA can be used for early screening of liver cancer.

When normal cells become cancerous, CpG regions of specific genes will be highly methylated, which will cause changes in chromatin structure, DNA conformation, DNA stability and the interaction between DNA and protein, thus affecting gene transcription and expression and inducing cancer development. Abnormal DNA methylation is a milestone in many tumors, which will appear in the early stage of tumor formation, so it is an ideal marker for early diagnosis of tumors. Therefore, selecting appropriate methylation biomarkers for screening is helpful for early detection and prognosis evaluation of cancer.

Is the accuracy of common liver cancer screening high at present? Routine tests for early diagnosis of liver cancer include AFP and US, but not all patients with liver cancer will have an increase in AFP, which is related to the size, quantity and characteristics of patients' tumors. Clinical data show that the diagnostic sensitivity of AFP is about 50-60%, and the missed diagnosis rate is 40-50%. Ultrasonic examination depends on the skills of professionals, so the screening effect is related to operating experience, and the sensitivity of early diagnosis is only about 33%. At present, early liver cancer usually has no obvious symptoms, but it usually has developed to the advanced stage, which greatly reduces the 5-year survival rate of patients.

Screening project: detection of alpha-fetoprotein (AFP) methylation gene Abdominal ultrasound (US) screening method Blood screening Non-invasive blood screening Non-invasive imaging medical screening Non-invasive screening sensitivity 84. 1% 60% 65% specificity 83.0% 80% 84% Detection of methylation gene of liver cancer has a breakthrough advantage.

People should pay special attention to the fact that there are 2 billion people suffering from liver diseases in the world, and there are about 750,000 newly diagnosed cases every year. The proportion of liver cancer in Asia ranks first in the world, and liver cancer still occupies the second place among the top ten cancer deaths in Taiwan Province Province in 17. At present, only improving the screening of liver cancer is the best way to prevent liver cancer. In the traditional screening tools for liver cancer, AFP tumor markers and abdominal ultrasound are used. Lv Changyi said that the sensitivity of early diagnosis of liver cancer has increased from 50% to 84. 1%, which can further realize the application of precision medicine in liver cancer management. It is worth noting that nearly 50% of patients with liver cancer can't detect the possibility of cancer, but 75% can be detected by methylation detection (MPM) of liver cancer.

Freepik created photos of people.

Subject: AFP, ctDNA, MPM, α-fetal protein, α-fetal protein, cancer screening, liver disease, liver cancer, liver cancer screening, ultrasound.