Why does Sophora japonica fried charcoal enhance the hemostatic effect?

Frying charcoal is a commonly used method of Chinese medicine concoction, and charcoal medicine is also widely used in Chinese medicine clinics. Modern mainly from the material basis of charcoal medicine hemostatic classification research, that the hemostatic effect of Chinese medicine fried charcoal is more complex, is a multi-component, multi-link, multi-target integrated effect, fried charcoal enhanced or produced hemostatic effect. From the ****components of the hemostatic effect of charcoal medicine, the author re-examined the issue of "components that enhance hemostatic effect after charcoal stir-frying", which is now reported as follows. Such as raw earth charcoal, lotus charcoal, etc. [1-3]. This is a more unified familiarity with the Chinese medicine charcoal to stop bleeding.

1. 1. 2 tannin effect on hemostasis tannin is widely present in medicinal plants, a complex polyphenolic compounds, can be combined with proteins, the formation of insoluble macromolecules, so it has an astringent, can play a protective role in the surface of the mucous membrane to stop excessive secretion, and inhibit excessive bleeding [4]. Such as the ground elm, acacia rice fried charcoal tannin content can be increased, and its hemostatic and antidiarrheal effects are also correspondingly strengthened [5].

1.1.3Ca2+ and the effect of trace elements on hemostasisCa2+ belongs to one of the body's coagulation factors, calcium in the plant after oral administration to form a soluble Ca2+, and participate in coagulation, such as palms stir-fried charcoal after the Ca2+ content increased significantly [6]. In addition, some traditional Chinese medicines, such as lateral cypress leaves and hawthorn, change the content of Zn, Mn, Cu, Fe, Ca and other trace elements after frying charcoal, and the hemostatic effect is enhanced compared with the raw products [4, 7].

1.2 According to the study of hemostatic site, hemorrhage can be divided into internal hemorrhage and external hemorrhage. Since most of the Chinese medicines are taken in soup, they are mainly used in the treatment of internal hemorrhage, such as gastrointestinal hemorrhage, hemoptysis of tuberculosis, etc., and their hemostatic effect is multi-component (such as charcoal, tannin, Ca2+, and trace elements and other components of hemostasis), multi-linked, multi-targeted effect; for the treatment of external hemorrhage, most of them are single-flavored traditional Chinese medicines such as Bacopa Monnieri, Folium Hepatitis [8], which is mainly a mechanical hemostasis of the compression effect.